Medicines That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) - Serotonin release by platelets plays an essential role in hemostasis. Epidemiological studies of the case-control and also mate layout that have demonstrated an organization in between use of psychotropic medications that interfere with serotonin reuptake and also the event of upper gastrointestinal bleeding have actually also revealed that concurrent use of an NSAID or pain killers potentiated the danger of bleeding. Therefore, patients ought to be forewarned concerning using such drugs simultaneously with citalopram.
Cimetidine - In topics which had received 21 days of 40 mg/day citalopram, integrated management of 400 mg/day cimetidine for 8 days led to a boost in citalopram AUC as well as Cmax of 43 % and 39 %, respectively. The professional importance of these searchings for is unknown.
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Digoxin - In subjects who had actually received 21 days of 40 mg/day citalopram, incorporated administration of citalopram and digoxin (solitary dosage of 1 mg) did not substantially impact the pharmacokinetics of either citalopram or digoxin.
Lithium - Coadministration of citalopram (40 mg/day for 10 days) as well as lithium (30 mmol/day for 5 days) had no significant impact on the pharmacokinetics of citalopram or lithium. Plasma lithium levels must be checked with ideal modification to the lithium dosage in conformance with basic professional technique. Care should be exercised when citalopram and also lithium are coadministered since lithium may improve the serotonergic impacts of citalopram.
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